Traditional Dosing  of Aminoglycosides & Vancomycin Dosing For Adults 
Marshall Pierce, PharmD

Use the tab key to navigate the form. Required data entry fields are teal in color.
Enter Age (years)
Enter Height in
Enter Actual Weight in
Select Sex
Enter Most Recent Serum Creatinine (mg/dl)
Enter Previous Serum Creatinine (mg/dl)
(Use the same value twice is if renal function is stable)
Enter time between serum creatinines (hours). Use 24 if renal function is stable. Creatinines should be > 1 T1/2 apart to accurately determine creatinine clearance when renal function is changing.
Select Drug
Enter Infusion Period (hours):
Aminoglycosides( 0.5-1 hours)
Vancomycin 2 hours (500 mg/hour)
   
Calculated Lean Body Weight (kg)
Calculated Drug Dosing Weight (kg)

Body Surface Area (Meters Squared)
DuBois & DuBois Formula

Calculated Weight Used In Creatinine Clearance Calculation
Calculated Creatinine Clearance (ml/min)
Pulse Dosing is the preferred method of Aminoglycoside Dosing when Clcr is  > 30 ml/min or elimination rate constant  of aminoglycosides is > 0.08784
Calculated T1/2 for CREATININE (hours)
Calculated Drug K (hours-1)
Pulse Dosing is the preferred method of Aminoglycoside Dosing when Clcr is  > 30 ml/min or elimination rate constant  of aminoglycosides is > 0.08784
Calculated Drug T1/2 (hours)
Calculated Drug Vd (liters)
Calculated Drug Vd (liters/dosing weight (kg))

Calculated Loading Dose (mg)
Gent/Tobramcyin ~ 2 mg/kg for level of 8 mcg/ml
Amikacin ~ 7.5 mg/kg for level of 30 mcg/ml
Vancomcyin ~ 20 mg/kg for level of 30 mcg/ml

Calculated Dose (mg)
Gentmicin/Tobramycin 1.5 mg/kg * Dosing Weight
Amikacin 7.5 mg/kg * Dosing Weight
Vancomcyin 15 mg/kg * Actual Weight
Enter Rounded Dose (mg)
Calculated Dosing Interval (hours)
Enter Dosage Interval (hours)
Calculated Peak (mcg/ml)
Maximum for Traditional Dosing:
  Amikacin 30 mcg/ml
  Gentamicin/Tobramycin  10 mcg/ml  
      Pneumonia 8-10 mcg/ml  
      Sepsis 6-8 mcg/ml  
      UTI 4-5 mcg/ml  
      Endocarditis 4-5 mcg/ml  
Calculated Trough (mcg/ml)
Maximum for Traditional Dosing:
Non Dialysis Patient 
  Amikacin 5 mcg/ml
  Gentamicin/Tobramycin  1.5 mcg/ml
  
Dialysis Patient 
  Amikacin 10 mcg/ml
  Gentamicin/Tobramycin  3 mcg/ml
  
Please complete the input boxes below if you have steady state levels and the time they were drawn. These values along with the entered dose, frequency, and infusion period will be used to find the patient's elimination rate constant (K) and Volume of Distribution (Vd).
Enter Measured Peak (mcg/ml)
Enter Time Peak Drawn From END of Infusion (hours)
Enter Measured Trough (mcg/ml)
Enter Time Measured Trough Drawn Before START of Infusion (hours)
Fit K (hours-1) 
Using Peak, Trough, Dosage Interval, Infusion Period, and Time of Levels.
Fit Vd (liters)
Using Peak, Dose, Dosage Interval, Infusion Period, Time of Peak, and Calculated K.
Thanks for using the program. If you have any comments or questions please contact the author.

Copyright Marshall A. Pierce, all rights reserved, no warranties expressed or implied.