• The initial dose of Cathflo will be the priming volume of the catheter lumen up to 1 ml (1 mg/ml). If the catheter volume is greater than 1 ml normal saline will be used to fill the remainder of the catheter.  If catheter patency is not established in 60 minutes an equal volume of alteplase will be re-instilled, up to 1 ml (1mg/ml).  The same vial will be used for the initial and follow up dose.
• When orders are written for CathFlo (alteplase) may repeat x1, the pharmacist will only send one 2 mg dose (2 mg/2ml). Nursing will call pharmacy if another vial is needed. 

Priming volumes for central venous catheters