Recommendations for Surgical Prophylaxis: MEC Approved

·       Use 2 gm of cefazolin (Ancef) for patients weighing greater than 100 kg.

• Patients with symptoms of CNS infections empirically, or evidence of CNS infections susceptible to ceftriaxone, should be given 2 gram doses of ceftriaxone at a dosing interval of every 12 hours.  Patients with gonococcal endocarditis may also require twice daily dosing.  Patients with endocarditis, febrile neutropenia, osteomyelitis, and Lyme disease should receive ceftriaxone 2 gram given daily.
• All other indications for ceftriaxone should be treated with 1 gram daily dosing.  Pharmacists will call the physician or leave a note for the physician recommending conversion to 1 gram daily unless the patient meets one of the above indications. If pneumococcal resistance is a concern Levaquin may be added and it covers atypical pathogens.